ISSN 2756-3413
African Journal of Virology Research ISSN 3421-7347 Vol. 13 (12), pp. 001-005, December, 2019. © International Scholars Journals
Full Length Research Paper
Some genetic characteristics of sabin-like poliovirus isolated from acute flaccid paralysis cases in Nigeria
Festus Doyin Adu1*, Jane Iber2, Tekena Harry3, Cara Burns2, Oluseyi Oyedele1, Johnson Adekunle Adeniji1, Mubarak Ossei-Kwasi4 David Kilpatrick2 Oyewale Tomori5 and Olen Kew2
1Department of Virology, College of Medicine, University of Ibadan, Nigeria.
2Division of Molecular Virology, Center for Disease Control and Prevention, Atlanta Georgia, USA.
3Dept of Immunology, University of Maiduguri Teaching Hospital, Maiduguri, Nigeria.
4Noguchi Memorial Institute for Medical Research Legon Ghana.
5WHO Regional Office Harare Zimbabwe
Accepted 10 August 2019
Abstract
A total of 34 sabin strains of the poliovirus isolated from 22 children with 60-day follow-up residual acute flaccid paralysis (AFP) were genetically characterized and screened for any form of recombination. Sequence analysis of the 906-nucleotide capsid showed that all the isolates were similar to their original sabin serotypes, however two of the viruses had drifted in their 3D noncapsid regions toward a sabin-sabin and sabin-nonpolio entero combination. Routine immunization in Nigeria is low and in spite of the increase in the frequency of supplemental immunizations, a lot of children are still inadequately immunized, which may be the reason for our observation in this study. Although we are not dealing with a case of circulating vaccine derived poliovirus (cVDPV) yet, if the above condition persists, the advent of cVDVP may not be too far. There is therefore the need to maintain a high quality mass immunization and sustained routine immunization.
Key words: Poliovirus, sequence, crossover, non polio enterovirus, recombination, genome, Sabin-like, vaccine, Nigeria.