ISSN 2169-303X
International Journal of Medicinal Plants Research ISSN 2169-303X Vol. 15 (3), pp. 001-009, March, 2026. Available online at www.internationalscholarsjournals.org © International Scholars Journals
Full Length Research Paper
Evaluating the Anti-inflammatory and Anti-hyperalgesic Properties of Stachys athorecalyx in CFA-Induced Rat Models
SH. Rezazadeh1, J. Zaringhalam2*, H. Manaheji2, A. Kebryaeezadeh3
1Institute of Medicinal plants, ACECR, Tehran, Iran.
2Department of Physiology, Neuroscience Research Center, Shahid Beheshti University, M.C., Tehran, Iran.
3Department of Pharmacology and Toxicology, Tehran University of Medical Science, Tehran, Iran.
Accepted 25 November, 2025
This study was aimed at investigating the possible anti-hyperalgesic and anti-inflammatory activities of pre-treatment and short term (6 days) administration of Stachys athorecalyx extracts during CFA- induced inflammation in male Wistar rats. Both methanolic and defatted extracts prepared from aerial parts of the plant were examined. The results showed dose related response in decreasing hyperalgesia and inflammation. The effective doses of both extracts were 100 mg/kg. The plant extracts were more potent in decreasing hyperplasia and inflammation compared with the standard drug (Indomethacin). By increasing the dose up to 200 mg/kg, there were no significant differences in pharmacological activities. Our results suggested that, aerial part of S. athorecalyx extracts suppress hyperalgesia and edema associated with acute and chronic CFA-induced inflammation.
Key words: Stachys athorecalyx, hyperalgesia, anti-inflammatory, CFA-induced inflammation.