International Journal of Medicinal Plants Research

ISSN 2169-303X

International Journal of Medicinal Plants Research ISSN 2169-303X Vol. 9 (12), pp. 001-011, December, 2020. © International Scholars Journals

Full Length Research Paper

Antimicrobial effect analysis of Verbena officinalis, Malva sylvestris and Ageratum conyzoides on Gardnerella vaginalis and Candida spp. isolated from vaginal secretionin Palmas, TO, Brazil

Valdir Francisco Odorizzi1, Mariana Caroline Tocantins Alvim2*, Adriana Idalina Torcato de Oliveira3, Eliane Patrícia Lino Pereira Franchi4, Juliana Fonseca Moreira da Silva5 and Raphael Sanzio Pimenta6

1Course of Medicine, Universidade Federal do Tocantins, Campus of Palmas, Brazil.[email protected]; +55 63 99999 6676.

2Course of Medicine, Universidade Federal do Tocantins, Campus of Palmas, Brazil.[email protected]; +55 63 99237 0177.

3Course of Chemistry, Universidade Federal do Tocantins, Campus of Araguaína, Brazil.[email protected]; +55 63 99282 2101.

4Course of Medicine, Universidade Federal do Tocantins, Campus of Palmas, Brazil. [email protected]; +55 63 99915 7102.

5Laboratory of General and Applied Microbiology, Universidade Federal do Tocantins, Campus of Palmas, Brazil.[email protected]; +55 63 98409 8649.

6Laboratory of General and Applied Microbiology, Universidade Federal do Tocantins, Campus of Palmas, Brazil.[email protected]; +55 63 98445 5036.

Accepted 23 November, 2020

Abstract 

Vaginitis is a condition that involves vulva and vaginal inflammation or infection, caused mainly by imbalance of vaginal microbiota. Its treatment is performed by the use of antimicrobials which are related with the appearance of resistant microorganisms, adverse effects and high rates of recurrence. Thus, interest in plants with antimicrobial activity has grown exponentially in academic area. For the first time, the antimicrobial activity of gervao (Verbena officinalis), malva branca (Malva sylvestris) and mentrasto (Ageratum conyzoides) ethanolic extractsis evaluated against clinical specimens of Candida spp. and Gardnerella vaginalis– important microorganisms in the etiology of vaginitis. Although the extracts did not present antifungal activity against Candida spp. specimens, the combination of the three extracts at 50, 100 and 200 mg.mL-1 exhibited antibacterial activity against all specimens of G. vaginalis. Gervao and mentrasto extracts combined at 50, 100 and 200 mg.mL-1were also able to inhibit the bacterial growth. Besides, those extracts had the lowest values of MIC (6.25 mg.mL-1), followed by the combination of mentrasto with malva branca– 6.25-25 mg.mL-1– and the combination of the three extracts – 12.5-25 mg.mL-1.Therefore, extracts of mentrasto and gervao are promising for the development of new strategies for the treatment of bacterial vaginosis.

Keywords:Verbena officinalis, Malva sylvestris, Ageratum conyzoides, Gardnerella vaginalis, Candida spp., antimicrobial activity.

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Juliana Fonseca Moreira da Silva and Raphael Sanzio Pimenta on Google Scholar Juliana Fonseca Moreira da Silva and Raphael Sanzio Pimenta on Pubmed Valdir Francisco Odorizzi on Google Scholar Valdir Francisco Odorizzi on Pubmed Eliane Patrícia Lino Pereira Franchi on Google Scholar Eliane Patrícia Lino Pereira Franchi on Pubmed Adriana Idalina Torcato de Oliveira on Google Scholar Adriana Idalina Torcato de Oliveira on Pubmed Mariana Caroline Tocantins Alvim* on Google Scholar Mariana Caroline Tocantins Alvim* on Pubmed