ISSN 2756-3855
International Journal of Urology and Nephrology Vol. 2 (4), pp. 059-062, December, 2014. © International Scholars Journals
Case Report
Lornoxicam-induced acute interstitial nephritis
Sibel Koçak Yucel MD1, Özlem Harmankaya Kaptanoğulları M.D1, Mürvet Yılmaz M.D1, Nilgün Akalın M.D1andAyşegül Kudu M.D .1
1Division of Nephrology, Department of Medicine, Bakırköy Dr. Sadi Konuk Teaching Hospital,Istanbul, Turkey.
Accepted 13 August, 2014.
E-mail: [email protected]
Abstract
Drug-induced acute interstitial nephritis (DI-AIN) is an important cause of reversible acute kidney injury.While antimicrobials and non-steroidal anti-inflammatory drugs are typically associated with drug-induced AIN,few reports have been made on the involvement of other analgesics.Side effects of nonsteroidal anti-inflammatory drugs (NSAIDs) most commonly affect the gastrointestinal tract and the kidney.This case report describes the first case of biopsy proven interstitial nephritis associated with acute renal failure in a patient treated withlornoxicamthe non‐selective inhibitior of cyclo‐oxygenase‐1 and ‐2. She presented with clinical findings of acute renal failure that required dialysis.The renal biopsy showed acute interstitial nephritis with a prominent eosinophilic infiltrate in the interstitium.She recovered normal renal function three weeks after cessation of lornoxicam and use of a corticosteroid (1 mg/kg/day).A course of oral prednisolone (1 mg/kg/day) was commenced andrapidly tapered to zero within three weeks.The renal function improved, and the patient was discharged with a creatinine of 0,75mg/dl (67 μmol/L).In general, the prognosis for drug-induced AIN is good and at least partial recovery of kidney function is normally observed. Early recognition is crucial because patients can ultimately develop chronic kidney disease.
Keywords:Acute interstitial nephritis, lornoxicam, corticosteroids, hemodialysis, acute renal failure.