ISSN 2756-3812
International Journal of Medical Advances and Discovery ISSN 2756-3812 Vol. 2 (2), pp. 001-005, February, 2011. © International Scholars Journals
Full Length Research paper
Response to tetanus vaccination in patients with type 2 diabetes mellitus
Ozluk O1, Kilic D2, Kaygusuz S3, Ceken S4, Agalar C2
1Department of Infectious Disease and Clinical Microbiology, State Hospital, Kırıkkale, Turkey.
2Department of Infectious Disease and Clinical Microbiology University of Kırıkkale, School of Medicine, Kırıkkale, Turkey.
3Department of Infectious Disease and Clinical Microbiology, University of Kırıkkale, School of Medicine, Kırıkkale, Turkey.
4Department of Infectious Disease and Clinical Microbiology, State Hospital, anlıurfa, Turkey.
Accepted 21 November, 2010
Abstract
Diabetes mellitus is an endocrine disease that profoundly affects the immune system. Inadequate regulation of blood sugar leads to immune defects and results in more frequent infections. Tetanus is an infectious disease that occurs more frequently in developing countries. Antitoxin levels against tetanus are reduced to inadequate levels 10 years after the last vaccination. The aim of the present study was to investigate the response to tetanus vaccination at 0, 1 and 12 months in 45 patients with type 2 diabetes mellitus and in 37 healthy volunteers who were not immune against tetanus. Immune response to tetanus vaccination was compared between the two groups at the fourth week after each vaccination. The p values were 0.207, 0.036 and 0.437 when antibody levels between groups were compared after the first, second and third vaccinations, respectively. A statistically significant difference was found between patients with disease duration of < 5 years versus > 11 years only after the second vaccination (p=0.02). The response of diabetic patients was similar to that of the healthy population probably because of the strong antigenic structure of the tetanus toxoid vaccine.
Key words: Tetanus, immunity, diabetes mellitus, immune response, vaccination.