ISSN 2756-3413
African Journal of Virology Research ISSN 3421-7347 Vol. 13 (4), pp. 001-004, April, 2019. © International Scholars Journals
Full Length Research Paper
Antiviral activity of Aloe vera against herpes simplex virus type 2: An in vitro study
Keivan Zandi¹*, Moloud Abbas Zadeh¹, Kohzad Sartavi² and Zahra Rastian¹
1Persian Gulf Health Research Centre, Bushehr University of Medical Sciences, Bushehr, Iran.
2Jahad Keshavarzi Research Centre, Bushehr, Iran.
Accepted 16 January, 2019
Abstract
In this study we tested the antiviral activity of a crude hot glycerine extract of Aloe vera gel which was grown in Bushehr (Southwest of Iran) against HSV-2 replication in Vero cell line. The extract showed antiviral activity against HSV- 2 not only before attachment and entry of virus to the Vero cells but also on post attachment stages of virus replication. The IC50 before attachment and entry of virus to the cells is 428 µg/ml and the CC50 value which is the cytotoxicity of the extract for Vero cells is 3238 µg/ml, while the calculated selectivity index (SI) is 7.56. Also, IC50 of extract on post attachment stages of replication is 536 µg/ml and the SI value for inhibition of the post attachment stages of HSV-2 replication is 6.04. Therefore, compounds of Aloe vera from Bushehr could be a good candidate as a natural source for antiviral drug development against HSV-2.
Key words: Aloe vera, antiviral, HSV-2, hot glycerine extract.