African Journal of Parasitology Research

African Journal of Parasitology Research ISSN 2756-3391 Vol. 11 (7), pp. 001-004, July, 2023. © International Scholars Journals

Full Length Research Paper

Studies on the immuno-bioactivities of the Oleaceae plant Nyctanthes arbor-tristis

M. Kannan^1*, A.J.A. Ranjit Singh², T.T. Ajith Kumar³, P. Jegatheswari⁴ and S.Subburayalu⁵

¹Microbiology Department, V.H.N.S.N.College, Virudhunagar-626 001, India.

²Department of Biology, Sri Paramakalyani College, Alwarkurichi–627412 India.

³CAS in Marine Biology, Annamalai University, Parangipettai – 608 502, India.

⁴Dhanalakshmi Srinivasan College for Women, Perambalur-621 212, India.

⁵K.R College of Arts and Science, Kovil Patti – 628 503, India.

Accepted 11 May, 2023

Abstract

In this study the immunomodulatory potential of an Indian medicinal plant, Nyctanthes arbor-tristis L. (Oleaceae), was investigated. The leaf extracts of N. arbor-tristis is used to treat arthritis, lung injury and some painful conditions such as cancer, chronic fever and rheumatism. An ethanolic extract of N. arbor-tristis (NAEE) was screened in rats for humoral and cell-mediated immune responses. Oral administration of the NAEE to rats at a dose of 50, 100, 150 and 200 mg/kg significantly enhanced the circulating antibody titre when challenged with sheep red blood cells (SRBC) and heat -killed Salmonella antigens. The chronic administration of NAEE increased the total counts of white blood cells (WBC) and potentated the delayed-type hypersensitivity (DTH) reactions. The present study confirms the strong immuno-bioactivities in extracts of Nyctanthes arbor-tristis L.

Key words: Immuno-bioactivities, Nyctanthes arbor-tristis, anti inflammatory, humoral immunity, delayed-type hypersensitivity.