ISSN 2326-7283
African Journal of Internal Medicine ISSN: 2326-7283 Vol. 2 (8), pp. 107-111, September, 2014. © International Scholars Journals
Full Length Research Paper
Tissue level antioxidant activity of leaf extract of Syzygium jambos linn. In paracetamol intoxicated Wistar rats
Nataraja Thamizh Selvam1*, Venkatakrishnan V2 and Damodar Kumar S3
1Research Scholar, Pachaiyappa’s College, Chennai, Tamil Nadu.
2Assistant Professor, Central University, Pondicherry,
3Professor and Head, Department of Chemistry, Pachaiyappa’s College, Chennai, Tamil Nadu. Email:[email protected]
Accepted 3 June, 2014.
Abstract
In recent years, oxidative stress and free radicals have been implicated in various diseases. Syzygium jambos, is a plant used by traditional physicians in Kerala, India for various ailments including wounds, ulcers and dermatopahty. The present study was undertaken to assess the antioxidant activity of methanolic extract of S. jambos leaf in paracetamol intoxicated Wistar albino rats. The rats were divided in to five groups of six animals each, categorized as healthy control group, disease control, standard group and two test groups. The test extract was administered in two difference doses as 100 and 200 mg/kg/ b.wt. The biochemical parameters SGOT, SGPT levels in blood and antioxidant profiles including of superoxide dismutase, catalase and glutathione levels in blood and different tissues (liver, kidney, heart) were evaluated. The results showed elevated levels of antioxidant enzymes in blood and tissues in treatment groups suggesting significant antioxidant activity.
Key words: Syzygium jambos, antioxidant activity, liver intoxication, oxidative stress, herbal medicine.