ISSN 2756-388X
International Journal of Plant and Animal Sciences ISSN 2167-0366 Vol. 7 (3), pp. 001-003, March, 2019. © International Scholars Journals
Short Communication
Effects of co-administration of chloroquine with paracetamol or ibuprofen on renal function of rabbits
Okey A. Ojiako1* and Harrison U. Nwanjo2
1Department of Biochemistry, Federal University of Technology, Owerri, Nigeria.
2Department of Medical Laboratory Sciences, Imo State University, Owerri, Nigeria.
Accepted 18 November, 2018
Abstract
The effects of co-administration of oral chloroquine with paracetamol or with ibuprofen on renal function were studied using 6 groups of New Zealand White rabbits. Group 1, the control group received only feed and water. The other groups (Groups 2-6) either received single therapies of paracetamol (10 mg/kg of body weight every 6 hours), ibuprofen (20 mg/kg of body weight/day) or chloroquine (5 mg/kg of body weight/day) or combined therapies of chloroquine and paracetamol or chloroquine and ibuprofen for 8 days. Measurements of serum urea, creatinine and electrolyte concentrations were used to assess renal function in these animals. The chloroquine-treated group had a significant (p<0.05) decrease in serum sodium and potassium concentrations and a significant increase (p<0.05) in serum urea and creatinine concentrations when compared with the corresponding values of the control group. The groups treated with combined therapy (groups 5 and 6) had significant increases (P<0.05) in serum urea and creatinine concentrations, and significant decreases in sodium and potassium levels when compared with the chloroquine-treated group (group 4) . These results confirm that acute administration of chloroquine impairs kidney function and further shows that this renotoxicity is exacerbated when chloroquine is co-administered with paracetamol or with ibuprofen, two common drugs used to manage fever.
Key words: Chloroquine, co-administration, paracetamol, ibuprofen renal toxicity.