ISSN 2326-7283
African Journal of Internal Medicine ISSN: 2326-7283 Vol. 10 (7), pp. 001-004, July, 2022. © International Scholars Journals
Full Length Research Paper
Antibacterial activity of extracts of Alchornea cordifolia (Schum and Thonn) Mull.Arg., Boerhavia diffusa (L) and Bridellia micranthaI (Hoscht) Baill. used in traditional medicine in Nigeria on Helicobacter pylori and four diarrhoeagenic bacterial pathogens
I. Adeleye Adeyemi1*, A. Ezekiel Omonigbehin2, Smith Stella2, Odusola Oluwatosin1 and Sobande Jumoke3
1Department of Botany and Microbiology, Faculty of Science, University of Lagos.
2Nigerian Institute of Medical Research, 6, Education Crescent, Yaba, Lagos, Nigeria.
3Department of Science and Technology, School of Applied Sciences, Yaba College of Technology.
Accepted 9 June, 2022
Abstract
Extracts of leaves of Alchornea cordifolia, Boerhavia diffusa and Bridellia micrantha were investigated for antibacterial activity against Helicobacter pylori, Salmonella typhi, Salmonella enteritidis, Shigella flexneri and Enteroheamorrhagic Escherichia coli (EHEC). Results showed that the ethanolic extracts of the three plants and aqueous extracts inhibited the growth of all the organisms tested. However, the minimal inhibitory concentration (MIC) ranged between 15.6 and 31.25 mg/ml while the extracts were bacteriocidal at concentration ranging between 31.25 and 250 mg/ml. This indicates that leaf extracts of the three plants are of great potential in treating gastric ulcer and diarrhoea caused by the aforementioned bacteria.
Key words: Alchornea cordifolia, Boerhavia diffusa, Bridellia micrantha, gastric ulcer, diarrhoea.