ISSN 2326-7275
International Journal of Anatomy and Physiology ISSN: 2326-7275 Vol. 2 (1), pp. 036-041, November, 2013. © International Scholars Journals
Full Length Research Paper
Effect of visfatin on blood glucose and serum lipids in normal and streptozotocin induced diabetic Rats
Mohamad Yosof Rezk
Department of Physiology, Faculty of Medicine, Zagazig University, Egypt.
*Corresponding author. E-mail: [email protected]
Accepted 08 October, 2013
Abstract
Visfatin is a novel adipokine showing altered plasma levels in different disorders, for example type-2 diabetes mellitus, obesity fetal growth retardation and gestational diabetes mellitus. We found that no study demonstrated the effect of visfatin on blood glucose and serum lipids in rats. Therefore, we investigated the effect of visfatin on blood glucose and serum lipids in rats. We found that visfatin produced an inhibitory effect on blood glucose level in a dose dependent manner and it caused further reduction in blood glucose level when combined with oral hypoglycemic drugs. We also found that visfatin produced a significant inhibitory effect on triglycerides, LDL and VLDL. These data are the first to show that visfatin can inhibit blood glucose in a dose dependent manner and the first to find an inhibitory effect on some serum lipids.
Key words: Visfatin, glucose, diabetic rats, oral hypoglycemic, obesity, adipose tissue.