ISSN 2326-7283
African Journal of Internal Medicine ISSN 2326-7283 Vol. 7 (4), pp. 001-007, April, 2019. © International Scholars Journals
Full Length Research Paper
Effect of a multi-fruit wine on some haematological parameters of male and female rats
Atamgba Agbor Asuk1*, Ofem Effiong Ofem2, Kazeem Olasunkanmi Ajeigbe3, Mbeh Ubana Eteng4 and Kingsley Omage5
1Department of Medical Biochemistry, Cross River University of Technology, Okuku-Campus, P.M.B 1123 Calabar, Cross River State, Nigeria.
2Department of Physiology, University of Calabar, Cross River State, Nigeria.
3Department of Physiology, Igbinedion University, Okada, Edo State, Nigeria.
4Department of Biochemistry, University of Calabar, Calabar, Cross River State, Nigeria.
5Department of Biochemistry, Igbinedion University, Okada, Edo State, Nigeria.
Accepted 26 November, 2018
Abstract
This study was aimed at evaluating the impact of wine obtained from a blend of five fruit extracts on some haematogical indices of male and female albino Wistar rats. Seventy male and female rats were randomly divided on the basis of body weight and sex into seven study groups. Group I (normal control) received normal diet and distilled water only, while the other groups except VI and VII (which had low doses of standard red and cashew wines respectively) received either low (corresponding to four standard drinks) or high (six standards) doses of the respective multi-fruit wine samples. Haematological indices determined showed that Hb and RBC values were not altered in both sexes compared with the control. The WBC values of all the test groups of female and male rats decreased significantly (P<0.05) compared with the normal control except H-MFWA (high dose of multi-fruit wine with additives) in females which compared well with the normal control. General decrease in MCV values of females and increase in males were significant (P<0.05) in some cases when compared with the normal control. Results of the investigation showed that sex differences associated with the handling of alcohol toxicity in the serum exist among male and female rats with the administration of multi-fruit wine. It also suggests the possible role of phytochemicals and wine additives in influencing the outcome of certain haematological parameters.
Key words: Haematological parameters, multi-fruit wine, phytochemicals, standard wines, wine additives.