ISSN 4391-3199
African Journal of Chemistry ISSN: 4391-3199 Vol. 3 (2), pp. 176-181, February, 2016. © International Scholars Journals
Full Length Research Paper
Synthesis of Azalactones involving the use of sodium acetate, anhydrous, KPO4 and calcium acetate
Omar Sami Hamama
Chemistry Department, Ain Shams University, Abbassia, Cairo, Egypt.
E-mail: [email protected]
Accepted 13 January, 2016
Abstract
Azalactone 1 can be synthesized via treatment of 4- chlorobenzoyl glycine with p-anisaldehyde in the presence of acetic anhydride and sod Acetate. The behaviour of azalactone 1 towards nitrogen nucleophiles, for example, anthranilic acid, 6-aminopyrimidin-2,4-dione and 2-amino-6-phenyl 1,3,4-thiadiazole can be investigated. Benzoxazone 2 can be treated with hydrazine hydrate, hydroxylamine hydrochloride, and o-phenylenediamine in different reaction conditions to afford quinazolinone derivatives 3, 4, 5, 6. The imidazoloquinazolinone derivative 6 can be treated with hydrazine derivatives. Pyrimidino/thiadiazolopyrimidine 8, 11 can be treated with acetic anhydride to increase their biological activities. The structures of all synthesized compounds were confirmed from analytical as well as spectral data.
Key words: Azalactone, benzoxazinone, quinazolinone, fused pyrimidinopyrimidine, 1,3,4-thiadiazolopyrimidine, Schiff’s base.