ISSN 2167-0447
International Journal of Agricultural Sciences ISSN 2167-0447 Vol. 10 (12), pp. 001-007, December, 2020. © International Scholars Journals
Full Length Research Paper
Effects of aqueous root extract of TRECULIA AFRICANA on blood glucose, lipid profile and body weight changes of streptozotocin-induced diabetic and normal rats
Omage Kingsley1*, Onoagbe, O. Iyere2, Erifeta O. Georgina1, Uhunmwangho S. Esosa1, Ajeigbe O. Kazeem3 and Amegor O. Frank4
1Department of Biochemistry, School of Basic Medical Sciences, College of Medicine, Igbinedion University, Okada, Edo State, Nigeria
2Department of Biochemistry, Faculty of Life Sciences, University of Benin, Edo State, Nigeria.
3Department of Physiology, School of Basic Medical Sciences, College of Medicine, Igbinedion University, Okada, Edo State, Nigeria
4Department of Medical Laboratory Science, College of Health Sciences, Igbinedion University, Okada, Edo State, Nigeria.
Accepted 19 August, 2020
Abstract
In this study, the effects of aqueous root extract of TRECULIA AFRICANA on blood glucose, triglycerides, total cholesterol, LDL-cholesterol, HDL-cholesterol and body weights of both STZ-induced diabetic and normal rats were investigated. Oral administration of aqueous root extract of TRECULIA AFRICANA at a dose of 200 mg/kg body weight per day, for a period of 14 days, caused a significant (p < 0.05) reduction in the blood levels of glucose, triglycerides, total cholesterol and LDL-cholesterol of both diabetic and normal rats. This dose also caused a significant (p < 0.05) increase in the HDL-cholesterol concentrations and body weights of both diabetic and normal rats. These effects portend the effectiveness of the plant in the management of diabetic conditions and hyperlipidemic states.
Key words: Streptozotocin (STZ), medicinal herbs, Treculia africana, lipid profile, hyperlipidemia, diabetes mellitus.