ISSN 2167-0447
International Journal of Agricultural Sciences ISSN: 2167-0447 Vol. 5 (3), pp. 472-475, May, 2015. © International Scholars Journals
Full Length Review Paper
Co-crystals of agrochemical actives
Bhupinder Singh Sekhon
PCTE Institute of Pharmaceutical Sciences, near Baddowal Cantt, Ludhiana-142 021, India.
Email: [email protected]
Abstract
Design of agrochemical active ingredients is a multidimensional task. Co-crystals are crystalline compounds that contain two different molecules that pack together in a fixed way. Co-crystallization can be used as a reliable technique to form alternative solid forms of agrochemical actives, and co-crystals do indeed have potential to increase the apparent solubility of compounds with poor dissolution properties. No marketed agrochemicals have been actively developed as co-crystals so far, but several companies are actively investigating them. Use of the Cambridge Structural Database which screens potential co-formers for a given active compound to find suitable, strongly interacting co-crystal partners is desirable.
Key words: Co-crystals, agrochemical actives, pesticides, solubility, co-formers.