African Journal of Parasitology Research

ISSN 2756-3391

African Journal of Parasitology Research ISSN 2756-3391 Vol. 7 (12), pp. 001-011, December, 2020. © International ScholarsJournals

Full Length Research Paper

Efficacy and safety of Artemether-Lumefantrine and Artesunate-Amodiaquine in the treatment of uncomplicated Plasmodium falciparum malaria in Northern Côte d'Ivoire

ASSI Serge-Brice1, OFFIANAN André Touré2, OUATTARA Lacinan3, ZIKA Kalou Dibert4, AOURA Carine Y. Josiane4, KADJO Marie-Ange K. Jocelyne4, SILUE Y. Ali4, LINGUE Kouadio Norbert1, COULIBALY Yalamoussa4, ADON Seka David4, ADOUBRYN Koffi Daho4

1Pierre Richet Institute / National Public Health Institute, Bouaké, Côte d’Ivoire

2Pasteur Institute, Abidjan, Côte d’Ivoire

3University NanguiAbrogoua, Abidjan, Côte d’Ivoire

4Medical Sciences Training and Research Unit, University Alassane Ouattara de Bouaké, Côte d’Ivoire.

Accepted 29 November, 2020

Abstract

Efficacy and safety of Artemether-Lumefantrine (AL) and Artesunate-Amodiaquine (AS-AQ) used as first line in malaria treatment were assessed in northern Côte d’Ivoire. A non-comparative therapeutic efficacy test of AL and AS-AQ in the treatment of uncomplicated falciparum malaria in children and adults was conducted from February to September 2019, in two sentinel sites. The WHO standard therapeutic efficacy test for monitoring antimalarial drug efficacy was used with Adequate Clinical and Parasitological Response (ACPR) corrected by PCR at day 28 as primary outcomes. Secondary endpoints were parasite and fever clearance times. A total of 119 patients were included in the trial with 59 treated with AL and 60 treated with AS-AQ. Per protocol analysis on day 28 showed a PCR-corrected cure rate of 100% (95% CI, 93.4-100.0) and 100% (95%CI, 93.2-100.0) for AL and AS-AQ, respectively. At day 3, three patients in the AL group presented a fever and all patients treated with AS-AQ were apyretic. Delayed parasite clearance was observed in three patients in the AL group and one patient in the AS-AQ group. Both ACTs remain efficacious and well-tolerated for uncomplicated falciparum malaria treatment in northern Côte d’Ivoire. However, due to delayed parasite clearance observed, close monitoring of efficacy is essential.

Key words: Malaria, Artemether-Lumefantrine, Artesunate-Amodiaquine, Efficacy, Safety, Côte d’Ivoire.

 

Download Full Text - PDF

ADON SD and ADOUBRYN KD on Google Scholar ADON SD and ADOUBRYN KD on Pubmed AOURA Carine Y. J on Google Scholar AOURA Carine Y. J on Pubmed SILUE Y. Ali on Google Scholar SILUE Y. Ali on Pubmed COULIBALY Yalamoussa on Google Scholar COULIBALY Yalamoussa on Pubmed LINGUE Kouadio Norbert on Google Scholar LINGUE Kouadio Norbert on Pubmed OUATTARA L on Google Scholar OUATTARA L on Pubmed ASSI Serge-Brice on Google Scholar ASSI Serge-Brice on Pubmed ZIKA KD on Google Scholar ZIKA KD on Pubmed KADJO Marie-Ange K. Jocelyne on Google Scholar KADJO Marie-Ange K. Jocelyne on Pubmed OFFIANAN AT on Google Scholar OFFIANAN AT on Pubmed