ISSN 2736-173X
African Journal of Malaria and Tropical Diseases ISSN 4123-0981 Vol. 8 (4), pp. 001-004, April, 2020. © International Scholars Journals
Full Length Research Paper
Evaluation of antiplasmodial activity of Berlina grandiflora leaf extract against Plasmodium berghei in mice
Akuodor G. C.1*, Anyalewechi N. A.1, Ikoro N. C.2, Akpan J. L.3, Megwas U. A.4, Iwuanyanwu T. C.1 and Osunkwo U. A.1
1Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development (NIPRD) Idu, P. M. B. 21, Garki, Abuja, Nigeria.
2Department of Optometry and Optical Technology, Federal University of Technology, Owerri, Nigeria.
3Department of Pharmacology and Therapeutics, Faculty of Clinical Medicine, Ebonyi State University, Abakaliki, Nigeria.
4Department of Optometry, Imo State University, Owerri, Nigeria.
Accepted 15 January, 2020
Abstract
The in vivo antiplasmodial activity of methanol leaf extract of Berlina grandiflora was investigated in Plasmodium berghei infected mice. Four day suppressive and curative effect against established infection models of antiplasmodial studies was used. The extract (100 to 400 mg/kg, p.o.) exhibited significant (p < 0.05) antiplasmodial activity in early and established infection tests with a considerable mean survival time comparable to that of chloroquine, 10 mg/kg. The leaf extract showed a significant (p < 0.05) activity against the parasite in the suppressive and curative tests. The finding supports the traditional use of the plant for the treatment of malaria.
Key words: Berlina grandiflora, medicinal plant, antimalarial activity, Plasmodium berghei.