ISSN 2329-9835
International Journal of Diseases and Disorders ISSN 2329-9835 Vol. 4 (2), pp. 001-004, February, 2016. © International Scholars Journals
Full Length Research Paper
Evaluation of Candida isolation from vaginal mucosa of mothers and oral mucosa of neonates on the basis of delivery type
Jamileh bigom Taheri1, Hamed Mortazavi1* ,Saeedeh Mohammadi2, Sedigheh Bakhtiari1, Fatemeh Namazi3,Naser Valaei4,Mahin Bakhshi1, Maryam Baharvand1, Nika Bahemmat2
1Department of Oral Medicine, Faculty of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
2Faculty of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
3Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
4Department of Nutrition ,Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Accepted 16 October, 2016
Abstract
Candida spp. is one of the most important fungal pathogens in the intensive neonatal care units associated with increased health care costs. This study was performed on 164 pregnant women (82 vaginal-routes and 82 cesarean-routes) and their infants. The vaginal samples were obtained using swabs from mothers prior to delivery. Swabs were taken from oral mucosa of all infants immediately after birth as well. Samples were inoculated onto Sabouraud dextrose agar and isolated species were obtained. Antifungal sensitivity was also evaluated against 3 different agents by disk diffusion method. The data were analyzed with Chi-square and Student t-test. Candida albicans and Candida krusei were the most common isolated species from mothers in vaginal and cesarean-route groups, respectively. Furthermore, C. albicans was the most common species in both neonate groups. There was significant difference in occurrence of Candida spp. on the oral mucosa between vaginally-born and cesarean-born infants whereas; there was no significant difference in occurrence of Candida spp. on the vaginal mucosa between mothers in vaginally and cesarean-route groups. Ketoconazole had higher antifungal activity in all studied groups. The type of delivery should be considered as a risk factor in neonatal candidiasis.
Key words: Candidiasis, neonates, cesarean and vaginal.