ISSN 2326-7267
International Journal of Pharmacy and Pharmacology ISSN 2326-7267 Vol. 13 (4), pp. 001-006, April, 2024. Available online at www.internationalscholarsjournals.org © International Scholars Journals
Full Length Research Paper
Evaluation of Iranian traditional cheese-derived Lactobacillus plantarum for gastric ulcer treatment in rats
Mitra Heydari Nasrabadi1, Helia Aboutalebi1*, Maryam Tajabadi Ebrahimi2 and Farima Zahedi1
1Department of Biology, Islamic Azad University, Parand Branch, Parand, Iran.
2Department of Microbiology, Islamic Azad University, Central Tehran Branch, Tehran, Iran.
Accepted 8 September, 2023
Abstract
Probiotics are living organisms which upon ingestion in certain numbers exert health benefits beyond inherent basic nutrition. The lactic acid bacteria are one of the most significant groups of probiotic organisms. These bacteria are commonly used in fermented dairy products and have been advocated for the treatment of gastrointestinal disorders. The aim of the present study is to investigate the effect of a probiotic strain Lactobacillus plantarum isolated from Iranian traditional cheese on gastric ulcer. Gastric ulcers were induced by luminal application of acetic acid (60% v/v) in rats. L. plantarum was given intragastrically at 1010 CFU/day for three, five, seven and fourteen consecutive days after ulcer induction. L. plantarum significantly reduced gastric ulcer area as compared to control and negative control groups. Neutrophils were strongly increased on day three and decreased on days five, seven and fourteenth after ulcer induction in treatment groups. Macrophages and fibroblasts significantly increased on three and five days after ulcer induction and decreased on days seven and fourteenth. These finding suggested that L. plantarum isolated from Iranian traditional cheese enhanced gastric ulcer healing via stimulating immune system and fibroblast increasing.
Key words: Lactobacillus plantarum, probiotic, gastric ulcer, healing.