African Journal of Malaria and Tropical Diseases

African Journal of Malaria and Tropical Diseases ISSN 4123-0981 Vol. 7 (5), pp. 001-005, May, 2019. © International Scholars Journals

Full Length Research Paper

Protein modeling of apical membrane antigen-1(AMA-1) of Plasmodium cynomolgi

D.M. Mamatha¹*, K. Nagalakshmamma¹, V.A. Dev Rajesh² and V.S. Sheerin³

¹Department Sericulture and Biosciences Sri Padmavathi women’s University, Tirupati, A.P, India. 517502.

²Department of Bioinformatics, Dravidan University, Kuppam, A.P., India.

³Department of Biosciences Sri Padmavathi women’s University, Tirupati, A.P, India. 517502.

Accepted 16 March, 2019

Abstract

Apical membrane Antigen-1(AMA-1), an asexual blood stage antigen of Plasmodium cynomolgi, is an important candidate for testing as a component of malarial vaccine. The degree of conservation of AMA-1 sequences implies a conserved function for this molecule across different species of Plasmodium. Since the AMA-1 of plasmodium cyanomolgi is yet to be structured, the authors have generated a homology model of AMA-1 by using the Swiss-PDB server. The protein’s conservity has been verified by performing multiple alignments using Bioedit and conserved domain database. The model was further checked for its correctness by predicting 2D and 3D structures, which validates the structure.

Key words: Protein model, AMA-1, apical membrane antigen-1, Plasmodium cynomolgi.