African Journal of Virology Research

African Journal of Virology Research ISSN 3421-7347 Vol. 5 (11), pp. 001-006, November, 2011. © International Scholars Journals

Full Length Research Paper

Microbial evaluation of some non-sterile pharmaceutical preparations commonly used at Al-khoms Market, Libya

Tamalli M.¹, M.A.B. Gamal², Bioprabhu Sangar³ and Alghazal M.A.⁴

¹Life Science Department, Microbiology Division, Faculty of Arts and Sciences, Al-margeb University, Libya.

²Microbiology and Immunology Department, Faculty of Pharmacy, Alazhar University, Egypt.

³Microbiology Department, Faculty of Medicine, Al-margeb University, Libya.

⁴Medical Laboratory Department, Faculty of Medical Technology, Misurata, Libya.

Accepted 01 October, 2011

Abstract

Pharmaceutical products of widely differing forms are susceptible to microbial contamination (Aulton,2002). The presence of microorganisms in a pharmaceutical preparations may therefore, affects the consumer, the preparation either itself or both depending on the class of contaminants. The use of contaminated pharmaceutical preparations has proved hazardous to the health of the users.To determine the type and incidence of predominant microorganisms in certainnon-sterile pharmaceuticals immediately after collection.All pharmaceutical samples were subjected to the following examinations: total bacterial count and presence of microbial pathogens, using conventional techniques.Microbial load varied among the pharmaceutical preparations. Bacterial counts ranged from 10 to more than 10³ CFU per ml org. Several measures, including equipment automation, monitoring programs and post-marketing surveillance are required to reduce the level of microbial contamination of non-sterile pharmaceutical products.

Key words: Pharmaceuticals, Microbial evaluation, Khoms market, Streptococci