ISSN 2736-1594
International Journal of Obstetrics and Gynecology ISSN 2736-1594, Vol. 10 (8), pp. 001-006, August, 2022. © International Scholars Journals
Full Length Research Paper
Metabolic and inflammatory consequences in women using selected methods of contraception
Ayodele A. Adelakun1*, Isaac O. Adediji1, Adeolu S. Oluremi1, John O. Imaralu2, Temitope O. Olusanya1, Olufemi J. Idowu3, Oyejide A. Olaniyan4, Peace I. Olawoore5, Victoria Adediji1, Oluwapelumi Alake1, Tomisin Onakoya1, Atinuke Ojo-Rowland1, and Opeyemi Sule1.
1Department of Medical Laboratory Science, Babcock University, Ilishan Remo, Nigeria
2Department of Obstetrics and Gynaecology, Babcock University, Ilishan Remo, Nigeria
3Department of Chemical Pathology, Bowen University, Iwo, Nigeria
4Department of Chemical Pathology, LAUTECH Teaching Hospital, Ogbomoso, Nigeria
5Department of Chemical Pathology, Olabisi Onabanjo University, Ago-Iwoye, Nigeria
Accepted 11th August, 2022.
Abstract
Hormonal contraception is associated with increased risk of obesity and cardiovascular diseases in women. We therefore studied the effect of different methods of contraception on insulin resistance and an inflammation biomarker. A total of ninety women were recruited - 25 implant contraceptive (IMC) users, 25 injectable contraceptives (INC) users, 10 oral contraceptive (OC) users and 10 intrauterine contraceptive device (IUCD) users, 20 non contraceptive users who served as controls. Anthropometric measurements were made and blood samples were collected for the determination of fasting plasma glucose (FPG), serum insulin and high sensitivity C-reactive protein (hsCRP), while Homeostasis model of assessment of insulin resistance (HOMA-IR) was calculated. We observed a significantly decreased HOMA-IR and serum insulin, in the IMC, INC and OC groups compared with the control. There was also significantly elevated waist circumference, waist-hip ratio and diastolic blood pressure in the test groups compared with the controls. In implants users, hsCRP showed a significant positive correlation with WC and FPG. In injectable users, hsCRP showed a significant positive correlation with BMI and WC. This study showed decreased serum insulin concentration among women using hormonal contraceptives and an association between serum hsCRP level and Waist circumference in them.
Key words: Contraception, Insulin resistance, anthropometric variables, inflammatory markers.