ISSN 2756-3855
International Journal of Urology and Nephrology ISSN 2091-1254 Vol. 6 (10), pp. 001-003, October, 2018. © International Scholars Journals
Short Communication
Acute effect of administration of ethanol extracts of Ficus exasperata vahl on kidney function in albino rats
Ijeh Ifeoma Irene and Ukweni Ajike Iheanacho
Department of Biochemistry, College of Biological and Physical Sciences and Department of Veterinary Physiology, Biochemistry and Pharmacology Michael Okpara University of Agriculture Umudike, P.M.B 7267 Umuahia Abia State Nigeria.
Accepted 13 March, 2017
Abstract
Administration of ethanol extracts Ficus exasperata. Vahl at doses 50, 200, 500 mg/kg body weight resulted in body weight gain in all extract - administered groups over a 3-day period. Mean relative kidney weight increased from 7.5 x 10-3 ± 8.7 x 10-4 in the control group to 1.2 x 10-2 ± 5.3 x 10-5 in the highest dose group. Serum urea concentration also increased in a dose dependent manner (4.35 ± 0.045, 4.70 ± 0.00, 5.06 ± 0.53, 5.50 ± 0.58) in groups I, II, III and IV respectively. Serum sodium concentration also increased from 44.95 + 10.94 in the control group to 98.85 + 0.0, 123 ± 1.95 and 152.0± 35.70 in groups II, III, and IV respectively. These findings suggest that the administration of ethanol extracts of Ficus exasperata. Vahl at high doses could affect kidney function.
Key words: Ficus exasperata.Vahl, kidney function, ethanol extracts, serum, sodium, urea.