ISSN 2756-3855
International Journal of Urology and Nephrology ISSN 2091-1254 Vol. 7 (5), pp. 001-006, May, 2019. © International Scholars Journals
Full Length Research Paper
The potential role of flaxseed oil on lead acetate-induced kidney injure in adult male albino rats
Ahmed E. Abdel-Moneim1*, Mohamed A. Dkhil1,2 and Saleh Al-Quraishy2
1Department of Zoology and Entomology, Faculty of Science, Helwan University, Egypt.
2Department of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia.
Accepted 18 January, 2019
Abstract
Lead (Pb+2) intoxication may initiate many disorders in humans and animals. This study investigated the role of flaxseed oil in protecting rats against Pb+2 exposures. The results showed that the administration of flaxseed oil efficiently protected albino rats against the Pb+2 caused injury, as revealed by some improvement in the histological structure of kidney as well as the restoration of the body weights loss of Pb+2 treated animals. At the same time, flaxseed oil decreased the levels of serum creatinine, blood urea nitrogen, uric acid, lipid peroxidation and nitric oxide production with concomitant elevation in glutathione, catalase, superoxide dismutase, glutathione reductase, glutathione-S-transferase and glutathione peroxidase activities. Thus, this study suggests the possibility of flaxseed oil usefulness in limiting toxicant induced by environmental heavy metals.
Key words: Lead, flaxseed oil, kidney, albino rat.