ISSN 2169-303X
International Journal of Medicinal Plants Research ISSN 2169-303X Vol. 9 (10), pp. 001-004, October, 2020. © International Scholars Journals
Full Length Research Paper
Effect of Mucuna pruriens on some haematological and biochemical parameters
G. K. A. Adepoju* and O. O. Odubena
Department of Clinical Pharmacy and Biopharmacy, Faculty of Pharmacy Olabisi Onabanjo University, Sagamu, Ogun State, Nigeria.
Accepted 16 August, 2020
Abstract
Mucuna pruriens (MP) has been pharmacologically studied for various activities like aphrodisiac, anti-diabetic, anti-microbial and anti-epileptics activities. The present study aims at investigating the effects of shade-dried seeds of M. pruriens on some haematological and bio-chemical parameters. Wistar strain albino rats of both sexes with weights ranging from 220 to 300 g were fed with shade-dried pul-verized seeds of M. pruriens in a 10-days experiment. The result shows that the Nigerian M. pruriens seeds improve the haematological and serum biochemical parameters determined in a dose-dependent manner. The study shows that shade-dried, pulverized seeds of M. pruriens lowers blood cholesterol, blood urea and serum creatinine. It also reduces bleeding time; increases platelet count and these were statistically significant (p<0.05). However, the effect on packed cell volume (PCV) was not statistically significant when compared with the control (p<0.05). Hence, shade-dried seeds of MP seeds are not poisonous when compared with the raw seeds.
Key words: Mucuna pruriens, arteriosclerosis, uremia, haemostatic ability, platelet count, creatinine, hyperchol-esterolaemia, hematological parameters.