ISSN 2756-3391
African Journal of Parasitology Research ISSN 2756-3391 Vol. 12 (9), pp. 001-007, September, 2024. Available online at www.internationalscholarsjournals.org © International Scholars Journals
Full Length Research Paper
Genotyping of HLA-DQA1 and HLA-DQB1 in Individuals Positive for H. pylori Serology
Nibras S. Al-Ammar1, Ihsan E. Al-Saimary1, Saad Sh. Hamadi2, Ma Luo2, Trevor Peterson1 and Chris Czarnecki2
1Department of Microbiology, College of Medicine, University of Basrah, Basrah, Iraq
2Department of Medicine, College of Medicine, University of Basrah, Basrah, Iraq
Accepted 19 July, 2024
Abstract
To study HLA-DQA1 and HLA-DQB1 genotyping in gastritis patients with positive RUT, this study was carried out in College of Medicine, University of Basrah. HLA-DQA1 and HLA-DQB1 genotyping was done in College of Medicine, University of Manitoba, Winnpeg, Canada during the period from 17th of April 2009 to 15th of July 2010. A total of 70 gastritis patients (29 males and 41 females) and 30 controls were included in this study. A significant increased frequency of DQA1*050101 and DQB1*020101 alleles was found in individuals (patients + controls) who showed (+RDT), but the association was weak (odds ratio = 0.39 & 0.33), as compared with individuals (patients + controls) with (- RDT). A significant decreased frequency of DQB1*050201 allele was found in individuals (patients + controls) with (+RDT). The association was very strong (odds ratio = 5.31), as compared with individuals (patients + controls) with (- RDT). A significant decreased frequencies of DQA1*0201 and DQB1*020101 alleles were found in gastritis patients with (+RDT). The association in DQA1*0201 was very strong (odds ratio = 6.38) and for -DQB1*020101 allele, the association was weak (odds ratio = 0.08), as compared with controls with (+ RDT). A significant increased frequency of DQA1*0201 allele was found in controls with (+ RDT) and the association was very strong (odds ratio = 6.18), as compared with controls with (- RDT). A significant increased frequency of DQB1*020101 allele was found in controls with (+RDT) but with weak association (odds ratio = 0.09), as compared with controls with (- RDT).
Keywords: H. pylori, seropositive, HLA-DQA1 & HLA-DQB1.