ISSN 2736-173X
African Journal of Malaria and Tropical Diseases ISSN 4123-0981 Vol. 3 (8), pp. 229-231, August, 2015. © International Scholars Journals
Full Length Research Paper
An investigation of antimalarial potential against Plasmodium berghei in infected mice
*Adejare Deala Adenike1, Adamu Philip Usman and Micheal David Dike2
1Department of Zoology, Faculty of Sciences, University of Port Harcourt, Port Harcourt.
2Department of Zoology, Faculty of Sciences, University of Nigeria, Nsukka, Nigeria.
*Corresponding author: E-mail: [email protected]
Accepted 12 July, 2015
Abstract
Antimalarial activity of the crude aqueous leaf extract of Pyrenacantha staudtii was evaluated using chloroquine-sensitive Plasmodium berghei infection in mice with an objective to finding scientific evidence for the use of the plant as traditional antimalarial remedy in Ido/Osi LGA of Ekiti state, Nigeria. The crude aqueous extract of P. staudtii Engl. (Icacinaceae) (100, 200 and 500 mg/kg) was administered orally to mice infected with P. berghei in 4 days suppressive test. The antiplasmodial effect during the test of the plant in blood was determined and the extract at these doses induced 58.0 to 63.4% activity in comparison with untreated (negative) control group. Chloroquine produced 100% activity. The antimalarial activity showed by P. staudtii during the test justifies its use in traditional medicine for treating of malaria in the area.
Key words: Pyrenacantha staudtii, herb, malarial, anti-malarial, Ido/Osi, Ekiti, Plasmodium berghei, mice.