African Journal of DNA and Cell Biology Vol. 1 (3) pp. 055-057, December, 2014. © International Scholars Journals
Review
Advances in DNA sequencing: Challenges and confinements of individual sequencing
*Amitabh V. Bihari, Vijay Hamid Mittal and Vishnu Gobind
Department of Biotechnology, Faculty of Medicine, Savitribai Phule Pune University, Pune, India.
E-mail: [email protected]
Accepted 04 November, 2014
Abstract
The advent of second and third generation DNA sequencing techniqnologies have revolutionized the genomics research. The Single Molecule Sequencing technologies are adequate to minimize occurrence of errors in sequencing. The third generation sequencing technologies could overcome limitations of first and second-generation sequencing technologies. The almost complete human genome sequencing was performed by using single molecular sequencing technologies. Benefits, risks and safeguards associated with the disclosure of information of very intimate kind contained in human genome, were also discussed. The power of whole sequencing for human welfare arises only from associations with medical histories, behavioral characteristics, physical descriptions and genome-environment interactions not from mere knowledge of base pairs.
Key words: DNA sequencing, medical histories, behavioral characteristics, physical descriptions.