ISSN 2736-1594
International Journal of Obstetrics and Gynecology Vol. 1 (2), pp. 015-019, October, 2013. © International Scholars Journals
Full Length Research Paper
Abnormal blood pressure and hyperandrogenemia in first degree relatives of women with polycystic ovarian syndrome referring to gynecology clinics of Shiraz Medical University
Akbarzadeh M*1, Moradi F2, Dabbaghmanesh MH3, zare N4 and Parsanezhed ME5
1Community Based Psychiatric Care Research Center, Department of Midwifery, Fatemeh (P.B.U.H) School of Nursing and Midwifery, Shiraz University of Medical Sciences, Shiraz, Iran.
2 Midwifery, University of Medical Sciences, Shiraz, Iran.
3Department of Internal Medicine, Endocrine and Metabolism Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
4Department of Biostatistics, Infertility Research Center, Shiraz University of Medical Sciences. Shiraz, Iran.
5 Department of Obstetrics & Gynecology, Infertility Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
*Corresponding author. Email: [email protected]
Accepted 30 September, 2013
Abstract
In women with polycystic ovarian syndrome (PCOS), increased prevalence of hypertension and abnormal androgen status is common. The study investigated the degree of hypertension (BP) and hyperandrogenemia in the first degree relatives of women with (PCOS) referred to a clinic affiliated to Shiraz University of Medical Sciences. This is a case-control study in which 107 first degree relatives of women with (PCOS) as case group and 107 individuals as control group were interviewed. Then, the first part of a questionnaire including demographic information was filled in, and the blood pressure measurements and blood samples were obtained to evaluate the serum levels of androgens. The data were analyzed through Chi-square. All statistical tests had 95% confidence intervals and alpha coefficient of 0.05. There was a statistically significant relationship between the mean BP of the experimental and control groups (p≤0.001) but no significant relationship was observed among the brothers. The mean testosterone in the experimental groups was significantly higher than the controls (p≤0.001). Testosterone levels in the parents of the experimental group than control group but no significant relationship between them (p≥0.05). The first degree relatives of women with (PCOS) are probably exposed to the risk of high BP and hyperandrogenemia. Screening for hypertension and other risk factors related to increased androgen (Hyperlipidemia, glucose tolerance, etc.) is essential.
Key words: Hypertension, hyperandrogenemia, polycystic ovarian syndrome, hyperlipidemia, androgen.