ISSN 2326-7283
African Journal of Internal Medicine ISSN 2326-7283 Vol. 8 (8), pp. 001-008, August, 2020. © International Scholars Journals
Full Length Research Paper
Effect induced by hemisuccinate of pregnenolone on perfusion pressure and vascular resistance in isolated rat heart
L. Figueroa-Valverde1*, F. Díaz-Cedillo2, E. Diaz-Ku1 and A. Camacho-Luis3
1Universidad Autónoma de Campeche, Av. Agustín Melgar s/n entre calle Juan de la Barrera y C-20, Col Buenavista C. P. 24039 Campeche Cam., México.
2Escuela de Ciencias Biológicas del IPN. Plan de San Luís y Díaz Mirón s/n Col. Santo Tomas, México, D. F. C.P. 11340.
3Facultad de Medicina de la Universidad Juárez del Estado de Durango, es Av. Fanny Anitua s/n Esq. Av. Universidad. C.P. 34000, Durango, Dgo., México.
Accepted 17 April, 2020
Abstract
Experimental studies suggest that pregnenolone can regulate blood pressure. Nevertheless, there is scarce information about the effects of pregnenolone and its derivatives at cardiovascular level. In addition, to date the cellular site and mechanism of action of pregnenolone at cardiovascular level is also unclear. In order, to clarify on those phenomena, we evaluated the effects of pregnenolone and hemisuccinate of pregnenolone on perfusion pressure in isolated rat heart using Langendorff flow model. Our results demonstrated that pregnenolone-derivative (10-9 M) significantly increase the perfusion pressure (p = 0.005) and vascular resistance (p = 0.006) in isolated heart. The activity exerted by hemisuccinate of pregnenolone on perfusion pressure (10-9 to 10-4 M) was blocked in presence of indomethacin (10-6 M) and montelukast (10-6 M).These data suggest that activity induced by hemisuccinate of pregnenolone on perfusion pressure and vascular resistance is dependent upon its chemical structure. This phenomenon possibly involves the thromboxane A2 (TXA2) synthesis and secretion.
Key words: Hemisuccinate of pregnenolone, Langendorff, perfusion pressure.