ISSN 2169-303X
International Journal of Medicinal Plants Research ISSN 2169-303X Vol. 9 (2), pp. 001-006, February, 2020. © International Scholars Journals
Full Length Research Paper
Toxicological and phytochemical screening study of Mitragyna Inermis (willd.) O ktze (Rubiaceae), anti diabetic plant
Konkon, N. G1,2, Adjoungoua, A. L.2, Manda, P.3, Simaga, D2, N’Guessan, K. E.1 and Kone, B D.2
1Laboratory of Botany, Biosciences Training and Research Unity, University of Abidjan - Cocody (Ivory Coast) 22 BP1414 Abidjan 22 (Ivory Coast).
2Laboratory of Pharmacognosy, Training and Research Unity of Pharmaceutical and Biological Sciences, University of Abidjan - Cocody (Ivory Coast) 01 BP V34 Abidjan 01 (Ivory Coast).
3Laboratory of Toxicology, Training and Research Unity of Pharmaceutical and Biological Sciences, University of Abidjan - Cocody (Ivory Coast) 01 BP V34 Abidjan 01 (Ivory Coast).
Accepted 20 October 2019
Abstract
Mitragyna inermis leaves are used in Ivorian traditional medicine to treat diabetes. To situate tolerance limits, we determined acute toxicity threshold by the Overall Harmonized System of classification (SGH) using predetermined dose method and then we highlighted principal chemical groups responsible for pharmacological activity. The results allowed us to conclude that any dose of M. inermis leaves aqueous extract (300, 2000 and 5000 mg/kg) is lethal for the inoculated animals. LD50 is thus higher than 5000 mg/kg. These results suggest that the aqueous leaf extract of M. inermis could be used with some degree of safety by oral route. Phytochemical analysis revealed the presence of sterol, triterpene, polyphenol, flavonoïd, catechic tannin, saponoside and alkaloid, which conferred several pharma-cological activities on the leaves of the plant.
Key words: Mitragyna inermis, acute toxicity, lethal dose, GHS class, phytochemistry.