ISSN 2169-303X
International Journal of Medicinal Plants Research ISSN 2169-303X Vol. 14 (3), pp. 001-004, March, 2025. Available online at www.internationalscholarsjournals.org © International Scholars Journals
Full Length Research Paper
Investigating Flavonoid-Induced Glycemic and Lipid Regulation from Nelumbo Nuficera Leaves in a Diabetic Mouse Model
Taoying Zhou1*, Denghong Luo1, Xingyuan Li1 and Yunbo Luo2
1Department of Biology, HuangGang Vocational and Technical College, HuangGang 438002, P. R. China.
2College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, P. R. China.
Accepted 06 January, 2025
This study evaluated flavonoids extracted from lotus (Nelumbo nuficera Gaertn) on reducing hyperglycemia and hyperlipidemia in alloxan-induced diabetic mice. flavonoids from lotus(FLL) was orally administered once a day after 3 days of alloxan -induction at 50 and 200 mg/kg for 28 day, and the results showed that fasting blood glucose ,serum TC and TG levels were significantly decreased, whereas serum HDL-c level were increased. The dosage of 200 mg/kg is more effective than that of 50 mg/kg. In addition, FLL did not exhibit any toxic symptoms in the limited toxicity evaluation in male mice. The above results suggested that FLL could control blood glucose and modulate the metabolism of glucose and blood lipid. So we conclude that the FLL should be evaluated as a candidate for future studies on diabetes mellitus.
Key words: Hypoglycemic, hypolipidemic, flavonoids from lotus leaf.