African Journal of Ecology and Ecosystems

African Journal of Ecology and Ecosystems ISSN 9428-167X Vol. 3 (1), pp. 170-174, January, 2016. © International Scholars Journals

Full length Research Paper

Mutational Spectrum of β-Thalassaemia of Northern part of Odisha, India

Nibarana Satapathy and Bisnu Prasad Dash

Department of Bioscience and Biotechnology, Fakir Mohan University, Balasore, Odisha, India.

*Correspondingauthor.Email: [email protected]

Accepted 15 April, 2016

Abstract

Prevention of β thalassaemia requires knowledge for diagnosing the molecular analysis in the population at risk. This knowledge is particularly necessary when prevention control is applied to a multiethnic population. For this purpose, we are analyzing different populations from northern part of Odisha, India. During the study, we encountered about 98 patients from District Head Quarter Hospital of Mayurbhanj and Balasore district of Odisha. Molecular analysis of β gene mutation were showing that population showing IVS I-5(G-> C), cd 41/42(-CTTT), cd 8/9(+G), IVS I-1(G->T), cd 15(G->A), cd 30(G->C) as well as 619 bp deletion. In most cases, we found the IVS 1-5(G-> C) mutation and cd 41/42(-CTTT) mutation. The novel 619 bp deletion is the first report being analyzed in northern part of Odisha. The patient’s age group more prevalence in between 0 - 15 years and their hematological parameters were recorded.

Keywords: β thalassaemia, β gene mutation, IVS 1-5(G-> C), cd 41/42(-CTTT), cd 15(G->A) mutation.