ISSN 2756-3413
African Journal of Virology Research ISSN 2756-3413 Vol. 14 (3), pp. 001-003, March, 2020. © International Scholars Journals
Short Communication
Protective effect of Ziziphus mauritiana leaf extract on carbon tetrachloride -induced liver injury
Dahiru, D1*, William, E.T.2 and Nadro, M.S.1
1Department of Biochemistry, School of Pure and Applied Sciences, Federal University of Technology, P.M.B. 2076 Yola, Adamawa State, Nigeria.
2Department of Chemistry, Faculty of Science, Adamawa State University, P.M.B. 25, Mubi, Adamawa State, Nigeria.
Accepted 13 September, 2019
Abstract
Protective effect of ethanol extract of Ziziphus mauritiana leaf was studied on carbon tetrachloride-induced liver damage. Pretreatment of rats with 200 and 300 mg/kg body wt of Z. mauritiana leaf extract protected rats against carbon tetrachloride liver injury by significantly lowering aspartate aminotransaminase (AST), alanine aminotransamine (ALT), alkaline phosphatase (ALP), total bilirubin (TB), and lipid peroxide levels compared to control. The extract at both doses also significantly restored depleted levels of glutathione and vitamin E compared to control. Reduction in lipid peroxidation, restoration of glutathione and vitamin E levels indicate strong antioxidant property of the leaf. Phytochemical screening of the leaf extract of Z. mauritiana indicates probable presence of flavonoids, phenolic compounds, tannins and saponins.
Key words: Ziziphus mauritiana, carbon tetrachloride, non-enzyme antioxidants, lipid peroxidation.