ISSN 2167-0404
International Journal of Medicine and Medical Sciences ISSN: 2167-0404 Vol. 2 (12) pp. 271-272, December, 2012. © International Scholars Journals
Case reports
It is time to adopt a strategy of routine some thrombophilias screening in women with a confirmed history of venous thromboembolism or recurrent fetal loss
Sarra Klai1*, Najiba Fekih-Mrissa1, Mourad Bouricha2 and Nasredine Gritli1
1Unit of Molecular Biology, Department of Hematology, Military Hospital, Tunis, Tunisia.
2Local Hospital of Feriena, Kasserine, Tunisia.
*Corresponding author. E-mail: [email protected]
Received September 17, 2012; Accepted 19 December, 2012
Abstract
Vascular disease in pregnancy is a rare event. Inherited risk factors for vascular disease include factor V Leiden, prothrombin, methylenetetrahydrofolate reductase point mutations and Antithrombin, protein C and S deficiencies. Recent studies suggest that there is also a link between these inherited ththrombophilias and adverse pregnancy complications such as fetal loss as well as venous thromboembolism. Here we describe 2 young patients with cerebrovascular thrombotic events whose only risk factor was genetic thrombophilia. In patients, complete clinical evaluation and laboratory investigations, including a thrombophilia workup and full radiological assessment, were performed. Recently genetic thrombophilia was reported in association with venous thromboembolism and various complications of pregnancy. Although it is rare, thrombophilia must not be misdiagnosed.
Key words: Cerebral venous thrombosis, deep vein thrombosis, factor V Leiden, gestation, pregnancy losses.