ISSN 2756-3642
International Journal of Agricultural Extension and Rural Development ISSN 2756-3642 Vol. 9 (1), pp. 001-005, January, 2021. © International Scholars Journals
Full Length Research Paper
Effects of 8-epi-prostaglandin F2 and prostaglandin F2 on serum progesterone concentration and corpus luteum size in ewes
D. T. Yates*, L. J. Yates, D. M. Hallford and T. T. Ross
Department of Animal and Range Sciences, New Mexico State University, Las Cruces, NM 88003-003, New Mexico Agricultural Experiment Station, Mexico.
Accepted 21 November, 2020
Abstract
Prostaglandin F2 (PGF2 ) is luteolytic in sheep. This study assessed luteolytic ability of an isomer, 8-epi-PGF2 . Ten ewes were estrus-synchronized and blood serum was collected for 12 days and analyzed for progesterone concentration. Ewes were laparoscopically administered 200 µg 8-epi -PGF2 or PGF2 , or placebo in each ovary on day 8 and ovariectomized on day 13. Corpora lutea (CL) were weighed. Serum progesterone was reduced (P < 0.041) by PGF2a on day 9, but recovered to control levels (P = 0.646) by day 10. Interestingly, 8-epi-PGF2a increased (P < 0.050) serum progesterone on days 9, 10, and 12. However, area under curve for serum progesterone between days 8 and 12 did not differ (P = 0.165) among treatments. In ewes administered PGF2a, serum progesterone decreased sharply (P < 0.001) after treatment, but recovered (P = 0.217) to pre-treatment levels by day 11, indicating limited luteolysis after one-time dosage. Mean CL weight did not differ (P = 0.836) among treatments, but weight of largest CL was reduced by 8-epi-PGF2a (P = 0.032) and PGF2a (P = 0.015). One-time, intra-ovarian administration of 8-epi-PGF2a at this dosage did not cause luteolysis. Additionally, serum progesterone is capable of recovery from one-time, intra-ovarian administration of PGF2a.
Key words: 8-epi-prostaglandin F2 , luteolysis, prostaglandin F2.