Synthesis, Microcharacterization, and Antifungal Activity of Novel Aminosalicylic Acid Transition Metal Complexes

International Journal of Chemistry | Vol. 15, No. 9, September 2024 | pp. 65–72

DOI: 10.46882/2024/IJC/000191

Article Type: Original Research Paper

Title: Synthesis, Microcharacterization, and Antifungal Activity of Novel Aminosalicylic Acid Transition Metal Complexes

Names of Authors: A. A. Yusuf¹, P. K. Ghosh²*

Authors’ Affiliations:
¹Department of Chemistry, Ahmadu Bello University, Zaria, Nigeria.
²Department of Pharmaceutical Technology, Jadavpur University, Kolkata, India.

Abstract: The emergence of drug resistance among opportunistic fungal strains requires the structural modification of classic therapeutic agents via coordination to transition metal ions to boost clinical performance. This research outlines the synthesis, structural characterization, and in vitro antifungal testing of novel copper(II), nickel(II), and cobalt(II) complexes coordinated with 4-aminosalicylic acid ligands. The synthesized coordination compounds were profiled utilizing elemental analysis, molar conductance measurements, magnetic susceptibility, and FT-IR spectroscopy. Analytical metrics established a 1:2 metal-to-ligand stoichiometric coordination pattern for all complexes, corresponding to a general structural configuration of [M(ASA)₂Cl₂], where ASA represents the neutral aminosalicylic acid molecule. Molar conductance tests in DMSO indicated a non-electrolytic nature. FT-IR spectra confirmed that the ligand acts as a bidentate chelator, binding to the metal centers via the amino nitrogen and the carboxylate oxygen atoms. In vitro antifungal evaluation was conducted against Candida albicans and Aspergillus niger isolates via the disk diffusion test. The copper(II)-aminosalicylic acid complex demonstrated a two-fold increase in mycelial growth inhibition compared to standalone uncoordinated aminosalicylic acid, which is explained via cell permeability and chelation principles.

Keywords: Aminosalicylic acid; Metal complexes; Antifungal activity; FT-IR spectroscopy; Candida albicans; Chelation theory

Manuscript Timeline: Received: February 12, 2023; Revised: March 20, 2023; Accepted: April 15, 2023; Published: September 09, 2024.

Citation: Yusuf, A. A., & Ghosh, P. K. (2024). Synthesis, Microcharacterization, and Antifungal Activity of Novel Aminosalicylic Acid Transition Metal Complexes. International Journal of Chemistry, 15(9), 65–72.

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