ISSN 2169-303X
International Journal of Medicinal Plants Research ISSN 2169-303X Vol. 15 (3), pp. 001-005, March, 2026. Available online at www.internationalscholarsjournals.org © International Scholars Journals
Full Length Research Paper
Antioxidant Efficacy of Grape Seed Extract in Attenuating High-Dose Garlic-Induced Hematological and Plasmatic Toxicity
Sonia Hamlaoui-Gasmi1*#, Meherzia Mokni1#, Nadia Limam1, Ferid Limam2, Mohamed Amri1, Ezzedine Aouani2 and Lamjed Marzouki1
1Laboratoire de Neurophysiologie Fonctionnelle et Pathologies, Département des Sciences Biologiques, Faculté des Sciences de Tunis. Campus Universitaire El Manar II-2092 Tunis, Tunisie.
2Laboratoire des Substances Bioactives, Centre de Biotechnologie, Technopole Borj-Cedria, BP-901, 2050 Hammam-Lif, Tunis, Tunisie.
Accepted 5 October, 2025
High dosage garlic exerts adverse health properties and grape seed extract (GSE) exhibit a variety of beneficial effects, even at high dosage. In the present study we evaluated the toxic effect of high dosage garlic treatment on blood parameters and the protective effect of GSE co-treatment. Rats were intraperitoneally injected with 5 g/kg body weight (bw) crude garlic extract during one month and co-treated or not (vehicle 10% ethanol) with GSE (500 mg/kg bw). Blood parameters were evaluated. Data confirmed that high dosage garlic induced anemia, increased MCV, reduced the MCHC, but has no effect on MCH. Garlic also has no effect on glycemia, calcemia, natremia and kaliemia. GSE co-treatment counteracted almost all garlic’s effects. High dosage garlic induced a toxic effect into erythrocytes parameters and GSE has real contradictory property.
Key words: Garlic, grape seed extract, erythrocytes, hemoglobin, hematocrit, glycaemia, plasmatic electrolytes, administration mode.