ISSN 2169-303X
International Journal of Medicinal Plants Research ISSN 2169-303X Vol. 15 (3), pp. 001-003, March, 2026. Available online at www.internationalscholarsjournals.org © International Scholars Journals
Short Communication
Evaluation of the Reproductive Endocrine and Andrological Effects of Trichilia monadelpha Extract in Male Albino Rats
O. T. Oyelowo1*, O. L. Bolarinwa2 and O. A. Morenikeji3
1Department of Physiology, College of Medicine, University of Lagos, Lagos State, Nigeria.
2Department of Physiology, College of Health Sciences, University of Ilorin, Ilorin, Nigeria.
3Department of Zoology, Faculty of Science, University of Ibadan, Ibadan, Nigeria.
Accepted 10 October, 2025
A lot of anti-malarial drugs are known to have serious detrimental effects on the sperm indices in experimental animals as well as in man; although recently, some drugs have been shown to have no adverse effects on testicular functions. The dearth of information on the reproductive toxicity of Trichilia monadelpha, a potent antimalarial plant in West Africa, especially in the South Western part of Nigeria, makes this study important. The effects of the aqueous extract of T. monadelpha were studied on sperm motility, viability and counts and serum concentration of testosterone in male albino rats. Oral administration of 400 mg/kg/day of T. monadelpha stem extract was administered for 4 weeks. The control rats received the vehicle, and all treated rats had corresponding recovery groups. There was a significant increase in sperm motility and viability (P < 0.01) as well as an insignificant difference in the sperm counts (P > 0.05) and there was a decrease in the serum testosterone level at P < 0.01. The results suggested that the administration of T. monadelpha at a dose of 400 mg/kg/day that was employed in this study had no adverse effects on testicular functions in the rat.
Key words: Anti-malarial drugs, aqueous extract, sperm quality, testosterone, male rat.