ISSN 2326-7275
International Journal of Anatomy and Physiology ISSN: 2326-7275 Vol. 6 (4), pp. 001-006, April, 2017. © International Scholars Journals
Full Length Research Paper
Anti glioma effect of doxorubicin loaded liposomes modified with angiopep-2
Mei Danyu1,2, Gao Huile1,2, Gong Wei3, Pang Zhiqing1,2, Jiang Xinguo1,2* and Chen Jun1,2
1School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai, 201203, China.
2Key Laboratory of Smart Drug Delivery, Ministry of Education and PLA, 826 Zhangheng Road, Shanghai 201203, China.
3Academy of Military Medical Sciences, Beijing 100853, China.
Accepted 28 August, 2016
Abstract
The low-density lipoprotein receptor-related protein (LRP) was highly expressed in blood brain barrier and glioma cells. Angiopep-2 was a new and effective ligand of LRP. Herein, we present a novel brain targeting delivery system: doxorubicin (DOX) loaded angiopep-2 modified liposome (AL). The particle size of AL was 102 nm and the zeta potential was -9.8 mV, which was stable and suitable for brain targeting delivery. In the anti glioma study, AL group had the smallest average tumor volume, the strongest tumor apoptosis, gain more weight after treatment and longer median survival time than that of other groups. This proved that Angiopep- 2 modified doxorubicin liposomes had certain glioma targeting therapeutic effects and lower toxicity.
Key words: Angiopep-2, liposome, glioma, targeted drug delivery.