ISSN 2736-1594
International Journal of Obstetrics and Gynecology Vol. 1 (3), pp. 027-031, November, 2013. © International Scholars Journals
Full Length Research Paper
Experimental endometriosis reduction in rats treated with pioglitazone
HongYan Liu1, ShiXiu Liao1*, ShengLi Zhou2, DongYun Zhang2, HuiNa Liu3, XiaoLi Zhao4, Li Dong5, Dong Wu1, Tao Wang1, Yan Chu1, QiaoFang Hou1, QianNan Guo1, Tao Li1, Li Wang1, Miao He1, HuiRu Zhao1, Ke Yang1, Chaoyang Zhang1, Feifei Huang1 and Yanli Yang1
1Medical Genetics Institute of Henan Province People’s Hospital, Zhengzhou, Henan 450003, China.
2Henan Key Laboratory for Esophageal Cancer Research of The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan 450052, China.
3Obstetrics and Gynecology of Zhengzhou Central Hospital, Zhengzhou, Henan 450007, China.
4Obstetrics and Gynecology of Zhengzhou People’s Hospital, Zhengzhou, Henan 450052, China.
5Obstetrics and Gynecology of Henan Province People’s Hospital, Zhengzhou, Henan 450003, China.
*Corresponding author. E-mail:[email protected]n.
Accepted 27 February, 2012
Abstract
The objective of this paper was to assess the effectiveness of the pioglitazone on endometriosis in rats. The study was performed on 24 Wistar rats. Endometriosis induction was performed in 24 rats, which were divided into three groups: group I (model group); and group II, the treatment group, comprising the other 12 rats. After 3 months, pioglitazone was performed in all animals. Pioglitazone treatment seems to be effective in treatment of endometriosis.
Key words: Pioglitazone, endometriosis, uterine implant, NF-kB p65, IkBα.