ISSN 2756-3413
African Journal of Virology Research ISSN 3421-7347 Vol. 13 (6), pp. 001-002, June, 2019. © International Scholars Journals
Short Communication
Distribution of hepatitis B virus genotypes in 50 patients with chronic hepatitis B in Abidjan–Côte d’Ivoire in 2003
Kouassi-M’Bengue, A.1*, Ekaza, Euloge1, Attia. A.2 , Kacou N’Douba, A.1 and M. Dosso.1
1UFR des Sciences Médicales –Département de Bactériologie-Virologie, Institut Pasteur de Côte d’Ivoire.
2UFR des Sciences Médicales –Médecine Interne, Abidjan Côte d’Ivoire.
Accepted 13 march, 2019
Abstract
Hepatitis B virus (HBV) strains isolated worldwide have been classified into eight genomic groups deduced from genome comparisons and designated as genotypes A to H. In order to investigate the prevalence of HBV genotypes in Abidjan-Cote d’Ivoire, a total of 50 chronic hepatitis B patients from two teaching hospitals were enrolled. Patients who were HBs Ag positive in serum at least for 6 months, who had HBV- DNA in serum and elevation of ALT levels more than 1.5 times upper limits of normal, and who had percutaneous liver biopsy within 6 months were included and genotyped. Three genotypes (A, B and C) out of total eight reported genotypes so far were identified; genotype A was the most predominant in this collection appearing in 22 samples (55%). Mixed genotypes were seen in 12 (25.3 %) HBV isolates. Ten of these were infected with genotypes AB whereas one with genotypes BC. One patient was infected with 3 genotypes (A/B/C).
Key words: Hepatitis B virus, Genotypes, Nested-PCR, Cote d'Ivoire.