ISSN 2167-0404
International Journal of Medicine and Medical Sciences ISSN: 2167-0447 Vol. 3 (2), pp. 351-356, February, 2013. © International Scholars Journals
Review
Effect of human papilloma virus in HIV infected person: A mini review
Solomon Sisay1, Woldaregay Erku2, Mulugeta Belay3, Zufane Sisay2, Moges Tiruneh4, Desalegn Woldeyohannes5*
1Department of Biomedicine, School of Health Science, Dilla University, Dilla, Ethiopia
2Department of Medical Microbiology, Aklilu Lemma Institute of Pathobiology, Addis Ababa University, Addis Ababa, Ethiopia.
3Department of Tropical and Infectious Diseases, Aklilu Lemma Institute of Pathobiology, Addis Ababa University, Addis Ababa, Ethiopia.
4Department of Microbiology, School of Biomedical and Laboratory sciences, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia
5Department of Public Health, School of Medical and Health Sciences, Addis Ababa Science and Technology University, Addis Ababa, Ethiopia.
*Corresponding author. E-mail:[email protected]
Received 12 December, 2012; Accepted 14 February, 2013
Abstract
Human immunodeficiency virus (HIV) infected person has greater frequency and severity of human papilloma virus (HPV)-associated cervical dysplasia than uninfected person. One of the risk factors for HPV infection and subsequent neoplasia of lower genital tract is impaired cell mediated immunity like in HIV patients. There is no clear information about infection of HPV and HIV in the same cell, but there is evidence which indicates role of HIV on HPV at molecular level. The impact of HPV on HIV is not also clearly understood. Currently, no data suggest that HPV acts differently in HIV positive person, but HPV persist in the lesion. Treatment for HPV in HIV patients involves both correction of immuno-suppression and combination of standard treatment use to clear HPV. HIV sero-positivity is known to be associated with an increased prevalence of ano-genital HPV infections in both sexes. Little is known whether HPV vaccine in HIV positive person can mount and maintain protective antibody titer against HPV infection. HIV positive women should undergo gynecological examination and vaccination against HPV genotypes to prevent the development of cervical cancer. The objective of this review is to indicate the interaction of HPV with HIV in modulating pathogenesis and disease progression in co-infected individuals.
Key words: Human immunodeficiency virus (HIV), human papilloma virus (HPV), HIV infected person, effect, risk factor.