African Journal of Medicine and Surgery

African Journal of Medicine and Surgery ISSN 2756-3324 Vol. 11 (2), pp. 001-004, February, 2024. Available online at www.internationalscholarsjournals.org © International Scholars Journals

Full Length Research Paper

Efficacy of carbetocin in hemorrhage prevention during laparoscopic myomectomy

Man Yang, Chengyong Wu*, Xuezhen Wen, Mei Lin and Liping Li

Meizhou People’s Hospital, Mei Zhou, 514003, China.

Accepted 2 September, 2023

Abstract

The objective of this study was to evaluate the clinical effect and safety of carbetocin administered to prevent bleeding in laparoscopic myomectomy. A retrospective analysis of April, 2006 to April, 2011 laparoscopic myomectomy hand clinical data of 70 patients was carried out. The 70 patients were divided into treatment group and control group; the treatment group was given preoperative carbetocin, while the control group was given preoperative beta oxytocin after giving them oxytocin, which was administered in the same way as in the treatment group. Blood loss, operative time, postoperative hemoglobin (Hb) values, decrease exhaust time, and postoperative hospital stay were observed. All the patients were operated on successfully with no conversion to open surgery; 100% success rate was recorded in the treatment group as blood loss and operative time were lower in that group than in the control group, showing a significant difference (t = 5.31, 3.661; P < 0.05). After twenty-four hours, Hb decreased in the two groups; however, the value of the difference in the decrease was not statistically significant (t = 2.802; P > 0.05). In the treatment group, Hb value decreased after 72 h and hospital stay and discharge time after were significantly lower compared to the control group; the difference was significant (t = 4.902, 4.052, 4.088; P < 0.05). In both groups, no serious adverse reactions and occurrence of postoperative morbidity were observed. Carbetocin showed good clinical efficacy when given to laparoscopic myomectomy patients, causing less blood loss, shorter operative time, and rapid postoperative recovery; therefore, it is safe, reliable, and worthy of clinical application.

Keywords: Laparoscopy, myomectomy, bleeding, carbetocin.