ISSN 2167-0404
International Journal of Medicine and Medical Sciences ISSN: 2167-0447 Vol. 2 (12), pp. 269-270, December, 2012. © International Scholars Journals
Case Report
Rosuvastatin induced rhabdomyolysis–Rare case reported in Batticaloa
Pirasath S.1*, Jasotharan V.2, Sundaresan K. T.3
1 Post Intern Medical Officer, Teaching Hospital, Batticaloa.
2Medical student, Faculty of Health Care Sciences, Eastern University of Sri Lanka.
3Consultant Physician, Teaching Hospital, Batticaloa
*Corresponding author. E-mail: selladuraipirasath81@gmail.com
Received 09 July, 2012; Accepted 12 December, 2012
Abstract
We reported a case of rosuvastatin induced rhabdomyolysis in a patient, who presented with one week history of bilateral thigh, back and shoulder pain and easy fatigability associated with passing dark coloured urine for two days. His systemic examination reveals muscle tenderness. His investigations showed high blood urea (147 mg%), serum creatinine (2.4mol/L), creatine kinase (CK) (21,210 U/L) and with a significant increase in urine myoglobin. Even he has no risk factors; he was diagnosed as rosuvastatin induced rhabdomyolysis associated with acute renal failure. The drug was stopped on the first day of admission and the patient was initiated on intravenous fluid with cautious monitoring of serum electrolytes. On the following days, the level of creatine kinase and serum myoglobin returned towards normal and consequently he was discharged without statins but on dietary therapy. On follow-up evaluation, the patient was symptoms free, his serum creatinine was 0.7mol/L, whereas his LDL cholesterol was 119mg/dL. The rosuvastatin induced rhabdomyolysis is discussed and the danger of its use in low risk patients is emphasized.
Key Words: Cytochrome P450, rhabdomyolysis, rosuvastatin.