International Journal of Diseases and Disorders

International Journal of Diseases and Disorders ISSN 2329-9835 Vol. 2 (2), pp. 001-004, February, 2014. © International Scholars Journals

Full Length Research Paper

Quantitative changes of serum immunoglobulins A, G and M among patients with Hepatitis A

Vatev N¹, Stoycheva M²*, Petrov A² and Terzieva T³

¹Department of Hygiene, Ecology and Epidemiology, Medical University – Plovdiv, Bulgaria.

²Department of Infectious Diseases, Parasitology and Tropical Medicine, 4002 Bul. Vasil Aprilov 15A,

Medical University – Plovdiv, Bulgaria.

³Department of Central University Clinic Laboratory, Medical University – Plovdiv, Bulgaria.

Accepted 10 October, 2013

Abstract

There is evidence of change in the level of serum immunoglobulins (Ig) in patients with hepatitis A and attempts for these changes to be associated with the clinical course of the disease. The aim of this study is to establish the quantitative changes of IgA, IgG and IgM in hepatitis A patients and to evaluate their significance for the clinical course of the disease. A total of 125 persons were examined: 35 patients with prolonged form of HAV; 51 patients with self limited form of HAV; 35 healthy persons – control group. In comparison with the control group, a substantial increase of IgA, IgG and IgM was found in patients with prolonged form of HAV. In patients with self limited form of HAV, the increase was significant for IgG and IgA, and insignificant for IgM. The research on serum Ig supplements the research panel performed for patients with HAV and may have prognostic importance in determining the severity of the disease and the prolonged forms of HAV.

Key words: Hepatitis A, serum immunoglobulins, quantitative changes.