International Journal of Medical Advances and Discoveries

International Journal of Medical Advances and Discovery ISSN 2756-3812 Vol. 2 (4), pp. 001-003, April, 2011. © International Scholars Journals

Full Length Research Paper

Hypolipemic effects of methanolic extract of persea americana seeds in hypercholestrolemic rats

Asaolu, Modupe Fisayo^1*, Asaolu, Samuel Sunday², Oyeyemi Ajibade Olugbenga¹ and Aluko, Bukola Tola¹

¹Department of Biochemistry, University of Ado-Ekiti, Nigeria.

²Department of Chemistry, University of Ado-Ekiti, Nigeria.

Accepted 16 March, 2011

Abstract

In this study, our objective was to investigate the possible hypolipemic effect of Persea americana (PA) on hypercholestrolemic rats. Acute administration of cholesterol resulted in the elevation of total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDLC), very low density lipoprotein cholesterol (VLDLC) and reduction in high density lipoprotein cholesterol (HDLC). However, treatment with various doses of the methanolic extract of the seeds of Persea americana caused a significant reduction in the levels of TC, TG, LDLC and VLDLC while the levels of HDLC increased significantly. These effects were dose dependent as marked changes were observed at the highest concentration (300mg/kg) of the methanolic extract of Persea americana seeds. It was concluded that Persea americana seeds showed an hypolipemic effect and may serve as possible alternative treatment for hyperlipemia and hypertension.

Key words: Hypercholestrolemic, hypolipidemia, methanolic, persea americana, doses