ISSN 2169-303X
International Journal of Medicinal Plants Research ISSN 2169-303X Vol. 8 (7), pp. 001-007, July, 2019. © International Scholars Journals
Full Length Research Paper
Antibacterial effects of S-(-)-tulipalin B isolated from Spiraea thunbergii Sieb. on Escherichia coli, a major food borne pathogenic microorganism
Jiyoung Lee1, Jongsung Lee1, Jihee Lim1, Sanghee Sim2 and Deokhoon Park1*
1Biospectrum Life Science Institute, SK Ventium 101-701, #522 Dangjung Dong, Gunpo City, Gyunggi Do, Rep. of Korea.
2School of Biotechnology, Yeungnam University, Gyeongsan City, Gyeongsangbuk Do, Republic of Korea.
Accepted 08 May, 2019
Abstract
The crude ethanol extract of the leaves of Spiraea thunbergii Sieb. (Rosaceae) showed antibacterial activity against a food borne pathogen, Escherichia coli. Bioactivity-guided separation led to the isolation of a butyrolaton, 1(S-(-)-tulipalin B). The structure was determined from the interpretation of spectroscopic data (UV, MS, and NMR). The minimal inhibitory concentration (MIC) of compound 1 against E. coli was found to be 100/ml. In addition, we found the possibility that a methylene group may operate as a key factor in the antibacterial activities of compound 1 and the hydroxyl group may exert a synergistic effect with the methylene group.
Key words: Spiraea thunbergii Sieb., antibacterial activity, butyrolactones, S-(-)-tulipalin B, Escherichia coli.