Synthesis, Characterization, and Antifungal Profile of Novel Isoniazid-Based Transition Metal Complexes

International Journal of Chemistry | Vol. 8, No. 1, January 2017 | pp. 1–8

DOI: 10.46882/2017/IJC/000100

Article Type: Original Research Paper

Title: Synthesis, Characterization, and Antifungal Profile of Novel Isoniazid-Based Transition Metal Complexes

Names of Authors: A. A. Yusuf¹, P. K. Ghosh²*

Authors’ Affiliations:
¹Department of Chemistry, Ahmadu Bello University, Zaria, Nigeria.
²Department of Pharmaceutical Technology, Jadavpur University, Kolkata, India.

Abstract: The emergence of drug resistance among opportunistic fungal strains requires the structural modification of classic hydrazide derivatives via coordination to transition metal ions to boost clinical performance. This research outlines the synthesis, structural characterization, and in vitro antifungal testing of novel copper(II), nickel(II), and cobalt(II) complexes coordinated with isoniazid ligands. The synthesized coordination compounds were profiled utilizing elemental analysis, molar conductance measurements, magnetic susceptibility, and FT-IR spectroscopy. Analytical metrics established a 1:2 metal-to-ligand stoichiometric coordination pattern for all complexes, corresponding to a general structural configuration of [M(INH)₂Cl₂], where INH represents the neutral isoniazid molecule. Molar conductance tests in DMSO indicated a non-electrolytic nature. FT-IR spectra confirmed that isoniazid acts as a bidentate ligand, binding to the metal centers via the hydrazide carbonyl oxygen and the terminal amino nitrogen atoms. In vitro antifungal evaluation was conducted against Candida albicans and Aspergillus niger isolates via the disk diffusion test. The copper(II)-isoniazid complex demonstrated a two-fold increase in mycelial growth inhibition compared to standalone uncoordinated isoniazid, which is explained via cell permeability and chelation principles.

Keywords: Isoniazid; Metal complexes; Antifungal activity; FT-IR spectroscopy; Candida albicans; Chelation theory

Manuscript Timeline: Received: February 12, 2016; Revised: March 20, 2016; Accepted: April 15, 2016; Published: January 03, 2017.

Citation: Yusuf, A. A., & Ghosh, P. K. (2017). Synthesis, Characterization, and Antifungal Profile of Novel Isoniazid-Based Transition Metal Complexes. International Journal of Chemistry, 8(1), 1–8.

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