African Journal of Botany

African Journal of Botany ISSN: 3519-3824 Vol. 6 (1), pp. 001-006, January, 2018. © International Scholars Journals

Full Length Research Paper

Analysis of brain cell activation by nanosized particles of Ginkgo biloba extract

Shimada Shinji¹*, Tanaka Yasukazu², Waki Hatsue², Kon Kazuo², Iwamoto Machiko² and Maruyama Naoki²

¹Tian Li Medical Institute, 2-1-2 Higashi, Okegawa, Saitama 363-0013, Japan.

²Tokyo Metropolitan Institute of Gerontology, Research Team for Functional Genomics 35-2 Sakae-cho, Itabashi-ku, Tokyo, 173-0015, Japan.

Accepted 18 October, 2017

Abstract

It is quite difficult to treat Alzheimer's dementia, where one of the problems is inadequate absorption of drugs. Revolution in manufacturing drugs is expected by the development of nanotechnology. Animal test was conducted to see whether the Ginkgo biloba extract processed with nanotechnology changed the function of cerebral cortical synapses and hippocampal nerve action. Rats underwent euthanasia 1 month after nanosized G. biloba extract administered. Synthesis and release activity of acetylcholine was measured, also the population spike and excitatory postsynaptic potential measured using hippocampal slice. Additionally, measurement with quantum resonance spectrometer was performed for human blood, artery and cardiac muscle. The rats with nanosized G. biloba extract administered showed a trend of acetylcholine release from cerebral cortical synapses more promoted than the control rats. Also, these rats showed greater amplitude of population spike at hippocampal CA1 pyramidal cell layer than the control rats. Remarkable effect on human blood, artery and cardiac muscle was also indicated with quantum resonance spectrometer. Test result showed that the nanosized particles of G. biloba extract resulted in easier absorption. However, acetylcholine synthesis is not explained completely, and this is to be one of the research themes in nano-medicine to be solved.

Key words: Ginkgo biloba extract, brain cell activation, nanotechnology, synapse, acetylcholine, hippocampus.